Lirum Therapeutics’ LX-101 New Positive Data Selected for Presentation at the 2025 American Association for Cancer Research (AACR) Annual Meeting

New York, NY, April 29, 2025 (GLOBE NEWSWIRE) -- Lirum Therapeutics, Inc. (“Lirum”), an innovative clinical-stage biopharmaceutical company focused on the treatment of debilitating diseases, announced today that new positive data on LX-101 against an increasingly wide variety of cancer types was selected for presentation at the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago. LX-101 is a novel clinical-stage payload-bearing targeted therapy directed to the insulin-like growth factor 1 receptor (IGF-1R) being developed in oncology and autoimmune indications.

These presentations highlight LX-101’s broad activity and promise in a wide array of pediatric and adult cancers with well-established ties to the IGF-1R pathway. In the first presentation, co-authored with investigators from the MD Anderson Cancer Center, LX-101 demonstrated potent activity against Ewing’s Sarcoma in both in vivo and in vitro models, and against desmoplastic small round cell tumor (DSRCT) in in vitro models. Notably, these cancers have strong ties to IGF-1R, including DNA-level gene fusions (i.e., EWSR1-FLI1 in Ewing’s and EWSR1-WT1 in DSRCT) that affect this signaling pathway, thereby providing a strong scientific and clinical rationale for LX-101 in these indications of unmet medical need. The second presentation highlights LX-101’s broad potency against a host of IGF-1R-expressing common adult cancer types including lung, esophageal and stomach representing the potential for further market expansion.

The presentations are:

• LX-101, a Novel, Clinical Stage, Payload-Bearing Targeted Therapy Directed to the Insulin-Like Growth Factor Receptor (IGF-1R), Demonstrates Potent Anti-Tumor Activity in Ewing Sarcoma Animal Models and Desmoplastic Small Round Cell Tumors, and
• LX-101, a Novel, Clinical Stage, Payload-Bearing Targeted Therapy Directed to the Insulin-Like Growth Factor Receptor (IGF-1R), Demonstrates Potent Preclinical Anti-Tumor Activity Against Multiple Cancer Types with Elevated IGF-1R Expression.

Both presentations are available on the Lirum website (www.lirumtx.com) under the Investors and Media tab.

Given these promising results, new clinical trials with LX-101 are planned in pediatric indications with strong ties to the IGF-1/IGF-1R pathway, including Ewing Sarcoma, DSRCT, rhabdomyosarcoma, and gastrointestinal stromal tumor (GIST). In addition, Lirum is planning trials in adult patients with cancer types that are naturally enriched for IGF-1R. In parallel, Lirum is also focused on developing LX-101 in thyroid eye disease (TED), where IGF-1R has been clinically and commercially validated.

About Lirum Therapeutics, Inc.
Lirum is an innovative clinical-stage biopharmaceutical company focused on the treatment of debilitating diseases through the acquisition, development and commercialization of novel drug candidates with compelling mechanisms of action, regulatory pathways and commercial opportunities. Lirum’s lead candidate, LX-101, is a novel clinical-stage targeted therapy directed to the insulin-like growth factor 1 receptor (IGF-1R) with a differentiated mechanism of action. Lirum is developing LX-101 in oncology and autoimmune indications, including thyroid eye disease (TED). For more information on Lirum, please visit www.lirumtx.com.

Forward Looking Statements
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Company contact:

Matt Hoberman
Investor Relations
IR@lirumtx.com 
Phone: (646) 389-6015

Lirum Therapeutics, Inc.
1270 Ave of the Americas, 7th Floor
New York, NY 10020